Effects of atherogenic diet on hepatic gene expression across mouse strains
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منابع مشابه
Effects of atherogenic diet on hepatic gene expression across mouse strains.
Diets high in fat and cholesterol are associated with increased obesity and metabolic disease in mice and humans. To study the molecular basis of the metabolic response to dietary fat, 10 inbred strains of mice were fed atherogenic high-fat and control low-fat diets. Liver gene expression and whole animal phenotypes were measured and analyzed in both sexes. The effects of diet, strain, and sex ...
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Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA. Effects of atherogenic diet on hepatic gene expression across mouse strains. Physiol Genomics 39: 172–182, 2009. First published August 11, 2009; doi:10.1152/physiolgenomics.90350.2008.—Diets high in fat and cholesterol are associated with increased obesity and metabolic disease in mice and humans. To study the molecular basis o...
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Inbred mouse strains C57BL/6J (B6) (susceptible) and C3H/HeJ (C3H) (resistant) differ in atherosclerosis susceptibility due to a single gene, Ath-1. Plasma lipoproteins from female mice fed chow or an atherogenic diet displayed strain differences in lipoprotein particle sizes and apolipoprotein (apo) composition. High density lipoprotein (HDL) particle sizes were 9.5 +/- 0.1 nm for B6 and 10.2 ...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2009
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.90350.2008